Personal blog of Dr Alex Mendelsohn

Tag: mentalhealth

Breaking the connection with my smartphone

Alex claims that while smartphones are undoubtedly useful, they are also one of the fiercest opponents he has encountered in terms of mental health. The short, sharp, and seemingly never-ending rewards they offer can be intoxicating and almost impossible to remove once latched onto. Alex tried several methods to separate himself from his attention-sucking device, but nothing worked. He then tried using a screenless mp3 player, but the battery life was too short. Alex then decided to use a smartwatch as a proxy mp3 player to help break his connection with his smartphone. He was initially concerned about the battery life, but the expensive model he bought had a large battery that allowed him to use it throughout the day without needing to charge it constantly. Alex claims that he is finally free of the grip of his smartphone, although he still needs to use it occasionally.

Smartphones are the devil.

Okay, bit harsh. Smartphones are undoubtedly very useful. The “I got lost” excuse for arriving late is not valid anymore – a quick few taps in your mobile map app of choice and you can instantly find out where you are (and where you should be).

In terms of good mental health, however, smartphones are one of the fiercest opponents I have encountered. It isn’t necessarily the magnitude of the effect they have on my mood. It is the smartphone’s ability to cling to my brain like a leech. They are almost impossible to remove once latched. The short, sharp and seemingly neverending rewards smartphones offer are intoxicating. And this is putting it mildly.

Continue reading

How I found Amdisen’s original research papers

Alex describes his experience of taking lithium and his search for information on its pharmacokinetic properties. He wanted to calculate his peak serum concentration and find out his approximate lithium half-life using the exponential decay formula. However, he found that there was no semi-log plot in the literature and no mention of the dual half-life of lithium. He searched for papers on simulations of the pharmacokinetic curve and found references to multi-compartmental models. Eventually, he found a chapter on lithium pharmacokinetics in a book and learned that the two half-lives he observed corresponded to the alpha and beta phases of lithium removal from blood vessels after peak concentration, which could be described using multicompartment models.

When I first started to take lithium, I wanted to calculate my peak serum concentration using my 12-hour sample value. I knew it was going to be a very rough estimation, but for me, doing the calculation made me feel less anxious about toxicity.

My plan was to use the exponential decay formula 1 to find the peak concentration (assuming the peak occurred around five hours). I wanted to find out, given I knew my serum creatinine levels, what my approximate lithium half-life was. I went looking for data in the lithium pharmacokinetic literature to figure this out.

Continue reading

Last winter I decided to disregard GMT and stay at BST: why isn’t this a thing yet?!

The blog post describes the experience of dealing with the time shift that happens twice a year due to daylight saving time. Alex decided to stick to British Summer Time (BST) and adjust half of the clocks in their house to GMT, instead of adjusting their medication schedule. Initially confusing, Alex became accustomed to this change and felt that their mood was significantly better due to the later daylight hours of BST. Alex argues that year-round daylight saving time could be a better option than switching back and forth between BST and GMT.

There are very few upsides to living with a severe mental illness. One of them is quite a bit of free time. Previous times the clocks have gone back have been a nuisance to me. Especially since I started taking antidepressants. For whatever reason, my brain is very sensitive to the time I take them. If I take my dose late, even by only half an hour, my reality is thrown from side to side like a ship in rough seas.

To be taken safely, my medications have to be taken a set time apart (therefore at fixed intervals in the day). This means that twice a year the time I take my medication shifts by an hour each day. Why don’t you take your medication at the same time all year round? I hear you ask…

Continue reading