Hello to everyone who happened upon this blog. My name is Alex Mendelsohn*. There isn’t much here in the form of sunshine and flowers (unfortunately, I couldn’t find those emoji’s – all I could find were these red flags: đźš©đźš©đźš©). Instead, you are free to feast on a collection of thoughts from a physicist going through severe mental illness. Yippee!
Continue readingThis blog post is in reference to my article in the May 2023 edition of the Lancet Psychiatry – Lithium Story: Eight Guidelines, Eight Recommendations. It is adapted from notes I sent to one of the editors when constructing the article
In a previous blog post, I looked at two examples of imprecise language in a Grandjean and Aubry paper about lithium pharmacokinetics (which I used in my May 2023 Lancet Psychiatry article). In this post, to show that the problem is not limited to a single paragraph in a single review paper, I have included a couple more examples of unclear messaging.
Continue readingThis blog post is in reference to my article in the May 2023 edition of the Lancet Psychiatry – Lithium Story: Eight Guidelines, Eight Recommendations. It is adapted from notes I sent to one of the editors when constructing the article.
It might seem strange to say from someone writing a blog post criticising clarity and precision of language, but I personally find it very difficult to write clear and precise language. Goodness, if you could see my first-year PhD report!
But, because I had to work very hard to clarify the muddled thoughts in my head, I recognised mistakes in lithium pharmacokinetic literature similar to those I used to make in my writing.
In the Lancet Psychiatry article, I focus on the paper “Lithium: updated human knowledge using an evidence-based approach” by Etienne Marc Grandjean and Jean-Michael Aubry. It is an extensive collation of knowledge on lithium treatment. However, producing a paper with such breadth of knowledge, can in turn, lead to unclear and imprecise language given how much the authors are required to understand.
Continue readingThere are very few upsides to living with a severe mental illness. One of them is quite a bit of free time. Previous times the clocks have gone back have been a nuisance to me. Especially since I started taking antidepressants. For whatever reason, my brain is very sensitive to the time I take them. If I take my dose late, even by only half an hour, my reality is thrown from side to side like a ship in rough seas.
To be taken safely, my medications have to be taken a set time apart (therefore at fixed intervals in the day). This means that twice a year the time I take my medication shifts by an hour each day. Why don’t you take your medication at the same time all year round? I hear you ask…
Continue readingWith the ongoing uncertainty regarding one of my medications not looking to end anytime soon, I have tried to distract myself with other absurdities going on in the world. In this blog post, I have combined two: ChatGPT and Matt Hancock. I hope that regardless of your political background, you agree that the UK health secretary during the covid-19 pandemic, Matt Hancock, made many mistakes (some with terrible consequences). I have been in and out of the loop of his, frankly, bizarre story. So, I asked ChatGPT to write an article for me by the wisest person I could think of… Yoda.
Mistakes, Matt Hancock made, hmmm? The Conservative politician, he was, yes. Many errors, he made, hmm? Mistakes, let us discuss.
Continue readingImagine the scenario. Potential impurities are found in some HIV retroviral drugs that produce a small increase in the probability of contracting cancer over their lifetime. I think the last thing you would expect would be the immediate stoppage of the production of the antiretroviral drugs in question. Leaving a patient vulnerable to imminent death as HIV progresses to AIDS is of greater importance than a tiny increase in lifetime cancer risk.
Yet, in the world of mental health treatment, this type of scenario has recently unfolded with the stoppage of the supply of Bupropion (Zyban) in the UK, leaving me and many others without the drug keeping them out of depression.
Continue readingI went into the Christmas period with the goal of not putting on weight. Long story short, I failed. In the past, I have been very fortunate to have a metabolism quick enough to remove the excess fat from my waist. It only required a slight modification in diet. In the last few years I have made the definitely new discovery, that, erm, metabolism slows with age.
No matter, I thought. I shall jump on the bandwagon with all the other health-focused people in January – hoping I don’t fall off before February. First stop, counting calories.
Continue readingIn the past, I have been refused treatments that eventually worked, and had interactions with past clinicians that unintentionally drove me towards suicide, rather than away from it.
It took me a very long time to find a psychiatrist I trust. Once I did, we landed on a combination of medications that have progressively eased my symptoms over the last couple of years. I take one of these medications off-label (this means that the medication is licensed for another condition, not the one I am taking it for). My current psychiatrist is the first I have met willing to prescribe this medication.
Continue readingI wasn’t exactly a natural at experimental work. My undergraduate lab marks were, erm, not brilliant. A poor memory mixed with a lack of practical intuition, a good experimental physicist, does not make. So, it is a tad ironic that I decided to do a PhD in electron microscopy – a mostly experimental field.
I liked planning experiments and analysing their results. I just didn’t very much like doing them. Sessions on the electron microscope always felt clunky. I had to frequently stop doing the experiment to note down significant events in my lab book and I was not the best at deciding which ones were worthy. Actually, I was terrible at deciphering happenstance from important experimental happenings.
Continue readingI recently received an email from my mum with the subject heading “Dunhelm invisibility cloak”. The only words in the body were “Enjoy!” followed by three hyperlinks to Dunhelm’s website (a furniture store).
The first link was to a “Darcie the Deer” printed throw blanket. At first glance, nothing seemed out of the ordinary. I mean, the colour was not really to my liking, but other than that it seemed like a regular, relatively inexpensive, blanket. My joy levels had not exactly skyrocketed.
Continue readingThis is quite possibly going to be the most self-aggrandising article I will ever write. Maybe I have finally descended into pure and utter delusion. But the experimentalist in me strongly believes that what I say in the title is true. I think my life accidentally became the near perfect experiment to discover biochemical causes of anxiety.
“How did I miss this?” I say to myself. I had just found a case study by Catalano et al. [1] describing the development of panic attacks in two patients shortly after initiation of the antidepressant Sertraline. Importantly, the patients had no personal or family history of any anxiety condition. I had been searching for an article like this since 2015. It was now 2021.
Continue reading